GLP-1 Medications: The Science Behind Modern Weight Loss
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Dr. Sarah Mitchell
Published January 7, 2026
GLP-1 receptor agonists represent a breakthrough in medical weight management. Originally developed for type 2 diabetes, these medications have shown remarkable effectiveness for weight loss.
GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in your gut. It signals to your brain that you're full and slows stomach emptying, helping you feel satisfied longer.
Medications like semaglutide and tirzepatide mimic this natural hormone, but with longer-lasting effects. Clinical trials have shown average weight loss of 15-20% of body weight.
These medications are administered via weekly injections and work best when combined with lifestyle modifications including diet and exercise changes.
Side effects are generally mild and may include nausea, which typically improves over time. Your healthcare provider can help manage any side effects and adjust dosing as needed.
GLP-1 medications are prescribed for adults with a BMI of 30 or higher, or 27 or higher with weight-related health conditions.
About the Author
Dr. Sarah Mitchell
Chief Medical Officer
Dr. Sarah Mitchell is a board-certified endocrinologist with over 15 years of experience in hormone therapy and metabolic health. She leads the medical team at LIHV, ensuring all treatments meet the highest standards of care.
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